Dry powder inhalers (DPIs)

Vectura’s range of pre-metered foil blister DPIs has been developed to meet patients’ needs in inhalation therapy for asthma and COPD. The devices are low cost and easy to use, yet they meet challenging technical and regulatory requirements. The core technology and IP used in GyroHaler® has also been incorporated in a family of devices aimed at meeting future product development and partnering opportunities.

GyroHaler®

GyroHaler®

GyroHaler® is a cost-effective, multi-unit dose dry powder inhaler designed to deliver locally acting drugs to the lungs. The device has a Red Dot design award and is approved and marketed in Europe and other territories as Sandoz’s AirFluSal® Forspiro® (Forspiro® is the name Sandoz gave to Vectura’s GyroHaler® device). GyroHaler®, is suitable for the delivery of a wide range of respiratory drugs and offers:

  • foil blister strips of up to 60 pre-metered doses;
  • excellent moisture protection; and,
  • reproducible dose delivery in line with stringent regulatory expectations.

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Lever-operated

Lever-operated

The lever-operated DPI is based on the proven GyroHaler® platform and offers:

  • user interface that is familiar to many DPI patients;
  • foil blister strips of up to 60 pre-metered doses;
  • accommodation of the used blister strip; and,
  • key drug-delivery components from GyroHaler®, particularly key drug-contact components.

Open-inhale-close

Open-inhale-close

The open-inhale-close DPI is a development programme that is aimed at developing the simplest possible user interface in addition to incorporating technology and IP used in the GyroHaler® and lever-operated DPI. The open-inhale-close DPI offers:

  • simple single-step preparation of the dose; and,
  • key drug-delivery components from GyroHaler®.

Unit dose DPI

Unit dose DPI

The Unit Dose DPI is a high performance, reusable device. It uses the same foil blister material and filling technology as GyroHaler® for optimum dose consistency and protection, and is capable of delivering high doses of drug with high lung delivery efficiency. The Unit Dose DPI offers:

  • good blister emptying and high emitted dose (ED);
  • high fine particle fraction (FPF);
  • ability to deliver large payloads of drug;
  • low flow-rate dependency; and,
  • ability to deliver biologic drugs. 

SkyeHaler™

SkyeHaler™

Multi-dose DPI developed by Skyepharma has been approved for use in the US, as well as in over 30 other countries, with commercial-scale assets available. SkyeHaler™ has a differentiated and competitive image with patented elements offering proprietary protection for branded NCEs and premium generics. It also has the flexibility to deliver a range of formulations as a platform device and offers:

  • Simple ‘open-inhale-close’ operation with no wasted doses;
  • Breath-triggered for optimal delivery, confirmed by dose-counter;
  • Patent protected device with consistent high levels of performance;
  • Range of doses and formulations possible;
  • Compact premium image with adaptable appearance;
  • Efficient reservoir powder filling into the pre-assembled device; and
  • Low investment as manufacturing assets and infrastructure available.