Vectura has a long history and successful track record in the development of novel formulations. Vectura’s formulation technologies seek to achieve state-of-the-art inhaled delivery of dry powders for both small molecules and biologic drugs.
These novel formulation approaches, together with extensive know-how, have been applied to a broad range of DPI products, including both generic and branded/innovative products.
Vectura’s expertise enables us to achieve performance aligned with product delivery. For a generic product this will mean developing a formulation/device combination with performance to match the reference branded product both in laboratory testing and in the clinic. For a branded/innovative product the goal is to maximise performance as befits the target airways disease and mechanism of action of the drug. Vectura not only has extensive experience in the development of lactose blend formulations for small molecule drugs but also in the development of dry powder formulations of biologics.
Vectura has a range of industry-leading formulation technologies to facilitate the development of successful DPI products:
is a family of processes that primarily uses Force Control Agents (FCA) to improve the performance of inhaled formulations. PowderHale® enables:
creates high performance dry powder formulations by advancing PowderHale® FCA technology to optimise its placement on the formulation constituents.
Addition of magnesium stearate to DPI formulations. Offers:
spray drying particle engineering technology was developed to deliver dry powder biologics and can produce uniform mixtures of drugs and excipients and can be used to co-formulate multiple APIs in the same particle at a fixed ratio.
A wide range of biologic and small molecules have been successfully formulated including:
Addition of sodium cromoglycate to MDI formulations. Offers:
Addition of magnesium stearate to MDI formulations. Offers:
Addition of CO2 or N2O to MDI formulations. Offers:
Production of sub-micron particles stabilised in HFA propellant for pMDI delivery. Offers: