Device Platforms

Our commercially-validated proprietary DPI, pMDI, advanced mesh and jet nebuliser technologies are available to deliver a broad range of complex inhaled therapies, both novel and generics

Optimise the device selection based on the stage of development, molecule type, indication and patient considerations

Early stage of development? Looking to move fast into the clinic with a single-dose capsule, blister device, or nebuliser? We can also support your programme and ensure a fast, seamless transition to a commercial-ready device when required.

Dry Powder Inhalers (DPI)

Our dry powder inhalers are derived from the commercially-validated AirFluSal® Gyrohaler® platform, but with a range of user interfaces and payload volumes, giving you confidence of performance and a proven regulatory track record.

With options for proprietary unit- and multi-unit dose platforms, as well as off-the-shelf capsule devices, we can support your programme from early development through to a commercial-ready device.

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Further information

Our DPI capability includes:

A range of devices including multi-unit dose and single blister unit-dose devices

Simplicity of design and low component count

Robust and low cost

Intuitive user interface

Add-on or integrated connectivity (for Open-Inhale-Close/OIC device)

Consistent performance

Broad and long-term patent coverage

Metered Dose Inhaler (pMDI)

Pressurised metered dose inhalers remain an important device option for many patients.

All the components of a pMDI have important roles in determining the characteristics of the aerosol and drug delivery to the lung. With extensive expertise in pMDI development and lifecycle management, we can help develop a new pMDI product or optimise your formulation and device performance.

You can have confidence based on our track record of supporting successful pMDI developments including flutiform® and breath-actuated flutiform® K-haler®

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Further information

Our particular areas of expertise include:

Development of tailored solutions based on commercially-available pMDI devices

Optimisation of container closure systems to be compatible with pMDI formulations

Designed for high volume and low cost manufacture

Nebulisers

Our state-of-the-art breath-actuated nebulisers with guided inhalation have been developed to improve lung delivery for inhaled drugs, with the aim of achieving better clinical outcomes and/or shortened treatment times

A patient’s breathing pattern can impact the efficiency of drug delivery to different regions of the lung. Control of the inspiratory flow rate, the inspiratory volume of the inhalation, and the timing of aerosol delivery during the inspiration can materially affect how much drug gets to central or peripheral parts of the lungs. This is the basis of our proprietary, smart nebulisation technology.

With this guided inhalation, our nebulisers have the potential to deliver the aerosol efficiently to the lungs, tailored to the individual patient’s breathing capacity.

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FOX® VIBRATING MESH NEBULISER

The FOX® device is a small, handheld, breath-activated, battery-powered inhalation system that delivers nebulised liquid drugs with high performance using a vibrating mesh technology. The device is CE-marked and has 510(k) approval.

FOX® is suitable for the delivery of small molecules and biologics, formulated as solutions or nano-suspensions.

A version of the FOX® device was launched by Bayer in several EU countries as Breelib® for the delivery of Ventavis® (iloprost) nebulisation solution for the treatment of adult patients with primary pulmonary hypertension.

Further information

Use with solutions and nano-suspensions of small molecules and biologics

Low inspiration flow rate

Controlled inhalation volume

Guided inhalation and real-time feedback

Bluetooth®-enabled for connectivity for digital health applications, including monitoring adherence and compliance

AKITA® JET NEBULISER

The AKITA® JET device is a desktop, breath-actuated, inhalation system which uses proprietary positive pressure technology to assist drug delivery to the lungs. The device is CE-marked and has 510(k) approval.

The inhalation system is suitable for the delivery of small molecules and some biologics, formulated as solutions or suspensions.

The AKITA® JET guides the inhalation manoeuvre, providing real-time feedback and inhalation performance information.

Further information

Use with suspensions and solutions of small molecules and some biologics

Guided inhalation and real-time feedback

Breath actuation

Bluetooth®-enabled for digital health applications, including monitoring adherence and compliance

Potential to increase lung delivery efficiency and reduce drug dosage and/or treatment time

Other available services

Product Manufacturing

See how our in-house manufacturing facilities and equipment can support your programme

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Process Development & Technical Transfer

Scale-up from laboratory through to commercial scale

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Pharmaceutical Analysis

Comprehensive analytical services to characterise inhaled products

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Medical & Regulatory

All formulation, device, and development services are supported by our medical & regulatory group

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